- Network: Fox Sports 1, Fox Sports 2, UFC Fight Pass
- Venue: Ibirapueroa Gymnasium
- Location: Sao Paulo, Brazil
- Event Date: September 22, 2018 6:45PM
Main Card (10:30pm EST., Fox Sports 1)
Eryk Anders (11-1) vs. Thiago Santos (18-6)
Carlo Pedersoli Jr. (11-1) vs. Alex Oliveira (18-5-1, 2NC)
Sam Alvey (33-10, 1NC) vs. Antonio Rogerio Nogueira (22-8)
Renan Barao (34-6, 1NC) vs. Andre Ewell (13-4)
Randa Markos (8-6) vs. Marina Rodriguez (9-0)
Preliminary Card (8:30pm EST., Fox Sports 2)
Charles Oliveira (23-8, 1NC) vs. Christos Giagos (15-6)
Evan Dunham (18-7-1) vs. Francisco Trinaldo (22-6)
Ryan Spann (14-5) vs. Luis Henrique (10-4, 1NC)
Chase Sherman (11-4) vs. Augusto Sakai (10-1-1)
Preliminary Card (6:45pm EST., UFC Fight Pass)
Livia Renata Souza (11-1) vs. Alex Chambers (5-4)
Elizeu Zaleski Dos Santos (19-5) vs. Luigi Vendramini (7-0)
Thales Leites (27-9) vs. Hector Lombard (34-9-1, 2NC)
Ben Saunders (22-9-2) vs. Sergio Moraes (13-3-1)
Gillian Robertson (5-2) vs. Mayra Bueno Silva (4-0)
