Letson (5-1-0) is undefeated thus far under the UFC banner, having defeated Julija Stoliarenko by split decision at the UFC Ultimate Fighter 28 Finale. Letson is going to enter the bout on the strength of a five fight winning streak and she hasn’t been defeated in almost five years. Letson also went undefeated as an amateur MMA fighter, which includes a victory over PFL veteran Moriel Charneski.
Santana (3-1-0) is winless thus far in UFC competition, having dropped a bout to Bea Malecki at UFC Fight Night Stockholm. Santana has competed just once in the last year-plus, with the aforementioned UFC bout being that lone encounter. Santana previously competed in the Watch Out Combat Show promotion, where she picked up two wins by way of decision.
UFC Fight Night Sao Paulo takes place on Saturday, November 16 from the Ibirapueroa Gymnasium in Sao Paulo, Brazil with no main event announced at this time. Fightful is going to be providing live coverage of the event, which streams live on ESPN+.