- Nasrat Haqparast lost via knockout or TKO for the first time in his career on Saturday night.
- Alexey Oleynik became the first UFC fighter to have MMA fights in the 90s, 00s, 10s and 20s. He also has wins across all four decades.
- UFC 246 featured three former UFC Champions in Conor McGregor, Anthony Pettis and Holly Holm, and four former title challengers in Donald Cerrone, Raquel Pennington, Roxanne Modafferi and Tim Elliott.
- After winning his first three UFC fights, all at heavyweight, Justin Ledet has lost his next three, all at light heavyweight.
- Holly Holm hasn' had back-to-back wins since becoming UFC Champion in 2016.
- Roxanne Modafferi has had 11 fights in the last 33 months, including exhibition bouts. She's had nine fights in the UFC or TUF since August 2017
- Three fighters (Holly Holm, Alexey Oleynik and Roxanne Modafferi) on UFC 246 were all over 37 years old. All three ended up gaining victories.
- Drew Dober has now won five of his last six fights.
- UFC 246 was the first pay-per-view Donald Cerrone ever headlined. It was Conor McGregor's sixth.
- Donald Cerrone had 11 fights in between bouts in Las Vegas. Six of McGregor's last seven fights have been in Las Vegas.
- Donald Cerrone passed Jim Miller for most UFC fights of all-time with 33. Despite that, he doesn't rank anywhere near the top 5 of Octagon time total.
- Conor McGregor now has finishes across four different UFC weight divisions.