Rey Mysterio Not Medically Cleared To Compete At WrestleMania 41, Rey Fenix To Face El Grande Americano

Rey Mysterio is not medically cleared to compete at WrestleMania 41.

Mysterio announced that he won't be able to face El Grande Americano at WrestleMania 41 due to an injury suffered on Friday's WWE SmackDown.

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Rey Fenix will take his place.

BREAKING: El Grande Americano will be facing Rey at #WrestleMania tonight ... REY FENIX! -- pic.twitter.com/zuB1CUI1oc

— WWE (@WWE) April 19, 2025

Rey Mysterio is not cleared to compete tonight, but Rey Fenix will replace him.

We reported on the Fightful Select scoops thread and the Q&A that he was an option within WWE pic.twitter.com/3uFfu6tXqZ

— Sean Ross Sapp of Fightful.com (@SeanRossSapp) April 19, 2025

Mysterio teamed with Rey Fenix & Dragon Lee in a victory over American Made (Chad Gable, Julius Creed, & Brutus Creed) on WWE SmackDown.

He was helped to the back after the match.

Fans can find Fightful's coverage of WWE WrestleMania 41 by clicking here.