- Network: ESPN, ESPN+
- Venue: Toyota Center
- Location: Houston, Texas
- Event Date: May 15, 2021 8:00PM
Main Card (10pm EST., ESPN+ Pay-Per-View)
UFC Vacant Lightweight Championship
#3 Charles Oliveira (30-8) vs. #4 Michael Chandler (22-5)
#5 Tony Ferguson (25-5) vs. #9 Beneil Dariush (20-4-1)
#2 Katlyn Chookagian (15-4) vs. #7 Viviane Araujo (10-2)
#9 Shane Burgos (13-2) vs. #13 Edson Barboza (21-9)
#8 Matt Schnell (15-5) vs. #9 Rogerio Bontorin (16-3, 1NC)
Preliminary Card (8pm EST., ESPN)
Ronaldo Souza (26-9) vs. Andre Muniz (20-4)
Lando Vannata (11-5-2) vs. Mike Grundy (12-2)
#11 Andrea Lee (11-5) vs. #12 Antonina Shevchenko (9-2)
Jamie Pickett (11-5) vs. Jordan Wright (11-1)
Early Preliminary Card (6:30pm EST., ESPN+)
Gina Mazany (7-4) vs. Priscila Cachoeira (9-3)
Kevin Aguilar (17-4) vs. Tucker Lutz (11-1)
Christos Giagos (18-8) vs. Joel Alvarez (18-2)
