Brett Okamoto of ESPN first reported the bout, which will serve as the co-main event of the show.
Nunes (19-4-0) will enter the title bout riding a ten fight winning streak and seven of those contests were title bouts. Nunes hasn’t suffered a defeat in over five years, with that last loss coming to Cat Zingano at UFC 178 in September of 2014. Nunes would be competing in her fourth straight co-main event bout and it has been almost two years since the double champion headlined a card.
Spencer (8-1-0) has won two of three under the UFC banner, with those wins coming over Megan Anderson and Zarah Fairn. Spencer is a former Invicta FC Featherweight Champion, defeating Pam Sorenson to win the gold at Invicta FC 32. Spencer has picked up eight wins as a professional MMA fighter and half of them came by way of submission.
UFC 250 takes place on Saturday, May 9 from the Ibirapueroa Gymnasium in Sao Paulo, Brazil with Henry Cejudo and Jose Aldo headlining. Fightful is providing live coverage of the event, with a post-show podcast to follow.